Travel to Health

Selenium  ( Se ) is  an essential trace element (for example, you only need to eat 1-2 Brazil Nuts per day; see Table 2) of high importance for human health  . Studies have already identified associations between selenium deficiency and increased morbidity and mortality from viral infections, cardiovascular, and thyroid diseases, as well as prostate, gastrointestinal, and breast cancers . But, you do need to avoid overdosing on Se as warned by CDC: [17] Brazil nuts contain very high amounts of selenium (68–91 mcg per nut) and could cause selenium toxicity if consumed regularly. Acute selenium toxicity has resulted from the ingestion of misformulated over-the-counter products containing very large amounts of selenium. In 2008, for example, 201 people experienced severe adverse reactions from taking a liquid dietary supplement containing 200 times the labeled amount. Acute selenium toxicity can cause severe gastrointestinal and neurological symptoms, acute respirato...

Figure 1. The hallmarks of ageing (Source: [55]) The well-established nine hallmarks of aging include: [55] Genomic instability Shortening telomere length Epigenetic modifications Loss of proteostasis Video 2 ( 32:12 ) Deregulated nutrient sensing Mitochondrial dysfunction SIRT3 , an important stress-responsive deacetylase with cardio-protective and longevity enhancing properties involved in mitochondrial homeostasis , stem cells and tissue maintenance. [56,57] Cellular senescence Stem cell exhaustion Altered intracellular communication  (Video 2) have all been shown to be caused, at least in part, by sustained systemic inflammation . [45-54] Video 1. Can ageing be delayed, stopped or even reversed? BBC News (YouTube link ) Inflammatory Clock (or iAge) Inflammation plays a role in almost all chronic diseases of ageing including atherosclerosis, cancer, neurodegenerative diseases and diabetes. From the blood immunome of 1,001 individuals aged 8–96 years, Sayed et al. developed ...

Toll Like Receptor 7  ( TLR7 ) is a Protein Coding gene. Diseases associated with TLR7 include: [3] Immunodeficiency 74 Covid19-Related X-Linked   X-Linked Immunodeficiency 74 Among its related pathways are Viral mRNA Translation and Measles . Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and double-stranded RNA binding  (dsRBD). An important paralog of this gene is TLR8 . In this article, we will cover the below topics: Genetic Variation X-linked COVID-19 Risk Factor Raw Data on Your Genetic Data ( 23andMe ) How Does 23andMe Report Genotypes? All Markers Reported on 23andMe for TLR7 Gene Genetic Variation Genetic variation is the difference in DNA sequences between individuals within a population. Variants may be germline or somatic. A variant in itself is not “pathogenic”, whether it can be causally related to a phenotype observed in a patient is determined by other factors. When a variant is described to "cau...