Aging—Knowing the Basics
Figure 1. The hallmarks of ageing (Source: [55]) The well-established nine hallmarks of aging include: [55] Genomic instability Shortening telomere length Epigenetic modifications Loss of proteostasis Video 2 ( 32:12 ) Deregulated nutrient sensing Mitochondrial dysfunction SIRT3 , an important stress-responsive deacetylase with cardio-protective and longevity enhancing properties involved in mitochondrial homeostasis , stem cells and tissue maintenance. [56,57] Cellular senescence Stem cell exhaustion Altered intracellular communication (Video 2) have all been shown to be caused, at least in part, by sustained systemic inflammation . [45-54] Video 1. Can ageing be delayed, stopped or even reversed? BBC News (YouTube link ) Inflammatory Clock (or iAge) Inflammation plays a role in almost all chronic diseases of ageing including atherosclerosis, cancer, neurodegenerative diseases and diabetes. From the blood immunome of 1,001 individuals aged 8–96 years, Sayed et al. developed ...