Evaluating Liver Health: Understanding FIB-4 Calculation and Interpretation
Liver Disease Stages Cleveland Clinic encourages proactive screening for MASH ( metabolic dysfunction – associated steatohepatitis ), a progressive form of fatty liver disease previously known as NASH. [1] MASH currently affects an estimated 5 – 7% of U.S. adults, and its prevalence is projected to increase to about 7.9% by 2050, driven largely by rising rates of obesity and type 2 diabetes , according to studies published in Diabetes Care and by the American Liver Foundation . [2] What is FIB-4 Screening? MASH occurs when excess fat accumulates in liver cells, causing inflammation and cellular damage. Unlike many medical conditions that rely on a single screening test, MASH lacks a universal diagnostic tool. “ The most effective approach is a two‑step screening strategy, ” notes Dr. Laique. Calculate the Fibrosis‑4 (FIB‑4) index: This is performed using routine blood tests. Follow-up with VCTE (FibroScan): If the FIB‑4 index is elevated, vibration‑controlled transient ela...