Travel to Health

Drug delivery can affect drug pharmacokinetics , absorption, distribution, metabolism, duration of therapeutic effect, excretion, and toxicity.   Nanoparticles  (NPs) are thought to have potential for novel drug delivery and release purposes. Critical considerations for a successful nano based drug delivery system include its ability: To target specific tissues and cell types   Endocytosis  (uptake into the cells) Targeting agent (address tags) To escape from the biological particulate filter   Mononuclear Phagocyte System (clearance of unwanted particulate material) Clearance avoidance  Main NP research question—how is particulate material recognized and cleared? In this article, we will cover the above four highlighted areas. Figure 1. Endocytosis (Credit: Mariana Ruiz Villarreal LadyofHats - Own work) Biological Particulate Filter  Cells of  Mononuclear Phagocytic System  ( MPS ) are cells  responsible for the...

  Nanoparticles  (NPs) are thought to have potential as novel intravascular probes for  both diagnostic (e.g., imaging) and therapeutic purposes (e.g., drug delivery) .  Critical issues for successful nanoparticle delivery include the ability: To target specific tissues and cell types   Endocytosis  (uptake into the cells) Targeting agent  (address tags) To escape from the biological particulate filter   Mononuclear Phagocyte System  (MPS; clearance of unwanted particulate material) Phagocytes and Nanoparticles Protection from Clearance by MPS  Main NP research question—how is particulate material recognized and cleared? In this article, we will cover the above five highlighted areas.  Note that the below topics are parts of the design considerations, but will not discussed here. Reduction in toxicity while maintaining therapeutic effects Greater safety and biocompatibility Figure 1.   Endocytosis (Created by Mariana Ruiz...