Health Effects of Iron Overload and Benefits of Blood Donation (Updated 2026)
Iron overload —a buildup of extra iron—without treatment can permanently damage organs such as the liver, heart, and pancreas; endocrine glands; and joints. [23] Excess Iron can also increase your risk of cancer, heart disease, and premature death. [24] In this article, we will cover the following topics: Negative health effects of iron overload Benefits of blood donation for most people Note that always consult a physician for ferritin testing, full iron panel, and any phlebotomy/donation plan. Self-managed aggressive reduction risks anemia. Serum Ferritin Test Ferritin is a protein that stores iron and acts as a buffer against iron deficiency and iron overload. It is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Therefore, plasma ferritin is a good indirect marker of the total amount of iron stored in your body. However, ferritin is also an acute-phase react...