Tregs and Wound Healing
Cutaneous wound healing is a complex procedure involving the interaction between different cells in the injured tissue, including inflammatory cells, fibroblasts , keratinocytes , and endothelial cells . [7,8] These cells contribute to healing process by releasing various chemo-cytokines and growth factors in a cell type specific manner to stimulate inflammation, angiogenesis , wound contraction and remodeling. TGF-β is involved in a number of processes in wound healing: inflammation, stimulating angiogenesis, fibroblast proliferation, collagen synthesis and deposition and remodelling of the new extracellular matrix. Interestingly chronic, non-healing wounds often show a loss of TGF-β1 signaling. [13] There are several options for the treatment of cutaneous wounds, which are grouped into three categories: [5] Dressings Topical gels Engineered skin The process of wound healing has to be well orchestrated and disruption of this process, for instance due to the infection o...