Design Considerations for a Successful Nanoparticle Delivery System
Nanoparticles (NPs) are thought to have potential as novel intravascular probes for both diagnostic (e.g., imaging) and therapeutic purposes (e.g., drug delivery) . Critical issues for successful nanoparticle delivery include the ability: To target specific tissues and cell types Endocytosis (uptake into the cells) Targeting agent (address tags) To escape from the biological particulate filter Mononuclear Phagocyte System (MPS; clearance of unwanted particulate material) Phagocytes and Nanoparticles Protection from Clearance by MPS Main NP research question—how is particulate material recognized and cleared? In this article, we will cover the above five highlighted areas. Note that the below topics are parts of the design considerations, but will not discussed here. Reduction in toxicity while maintaining therapeutic effects Greater safety and biocompatibility Figure 1. Endocytosis (Created by Mariana Ruiz...