Design Consideration—Using Nanoparticles for Drug Delivery
The development of drug delivery systems entails a wide range of tasks familiar to the engineer: the development of materials suitable to the specific application (biodegradable, pH-sensitive, anionic , flexible, etc.), the attainment of a particular degree of drug loading and type of release kinetics (slow, fast, pulsatile), and proof of efficacy. To apply nanoparticle systems in drug delivery technology, there are many design considerations which will be discussed in the article. Design Considerations of a Drug Delivery System Drug delivery is the method of administering a bioactive compound to achieve a therapeutic effect, in humans or animals. Drug delivery systems are formulations that modify the drug release profile and the ability to cross biological barriers, the biodistribution and pharmacokinetics , improving its efficacy and safety, as well as the patient compliance . The general design considerations for a drug delivery system include: Potential interaction with tissues a...