Melatonin Controlling the Balance between Th17 & Treg Cells
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Melatonin’s role in immunomodulation remains under investigation; its use for autoimmune or inflammatory disorders should be undertaken only under specialist supervision. Both Treg dysfunction and hyperactive responder T-cell proliferation contribute to disease. In this article, we will discuss the importance of regulating between Th17 and Treg cells. F igure 1. IL‐6 mediates Th17 / Treg balance. IL‐6 induces Th17 differentiation from naïve T cells together with TGF‐β . On the other hand, IL‐6 inhibits Treg differentiation induced by TGF‐β . IL-6: Regulator of Treg/Th17 Balance Inflammatory T cells are thought to be central to the pathology of autoimmune diseases . Especially, the recently identified T‐cell subset, the Th17 cells, shows pro‐inflammatory functions and plays a critical role in various autoimmune disorders. Recent studies have de...