Gut Dysbiosis, Increased Permeability, and the Development of Autoimmune Conditions
Stop Wasting Money on Probiotics. Here’s What Actually Improves Gut Health (YouTube link ) The gut barrier follows a clear sequence described in Fasano’s model: A structural epithelial layer, tight junctions that regulate passage between cells, and zonulin, the key modulator that can open these junctions when triggered. Rather than repeating the full mechanisms here, readers can find a concise explanation of how these components work—and what activates zonulin—in the companion article : “ The Gut’s Gatekeepers: How Tight Junctions and Zonulin Shape Your Health .” Figure 1. Prevention of gut-barrier dysfunction in arthritis ameliorates joint inflammation [30] Increased Intestinal Permeability and Its Association with Autoimmune Diseases Recent studies indicate that increased intestinal permeability (often called ' leaky gut ') is commonly observed in many individuals with autoimmune diseases, though prevalence varies by condition and is n...