The Link between a Common Variant in HLA Genes and Asymptomatic SARS-CoV-2 Infection
So far most global efforts have focused on severe illness in COVID-19, for example: The Link between TLR7 Variants and Critical COVID-19 However, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promote rapid viral clearance . Asymptomatic COVID-19 At least 20% of people who become infected with the SARS-CoV-2 coronavirus never feel sick . [4-7] Now scientists have identified a genetic mutation (i.e., HLA-B*15:01 ) that is linked to a higher likelihood of avoiding symptoms during infection. [1] Here variation in the human leukocyte antigen (HLA) loci may underly processes mediating asymptomatic infection was postulated . Initially, scientists suspected that this genetic association is due to pre-existing T cell immunity . After further study, now they show that: The structural similarity of the peptides underpins T cell cross-reactivity of high-affinity public T cell receptors , providing...