Travel to Health

Attention: Click  here  to view a mobile-friendly version.   In the aging human eye, oxidative damage and accumulation of pro-oxidant lysosomal lipofuscin cause functional decline of the retinal pigment epithelium (RPE), which contributes to age-related macular degeneration . There’s a known decline in the of RPE cell function in age-related  macular degeneration . These are the photoreceptor support cells in the retina that are critical for the process of light into sight conversion. The RPE dysfunction is caused by : [11]    A build-up of metabolic waste products in the RPE called lipofuscin . An RPE oxidation burden that compromises important metabolic pathways . The ensuing dysfunction, distress and sometimes death of the RPE cells results in age related  macular degeneration . However, researchers believe that the real causes of MD could be multifactorial: Hereditary or genetic predisposition Environmental Nutritional But, age is the st...